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PROTONIX (pantoprazole sodium) For Delayed-Release Oral Suspension, 40 mg, contains the active ingredient pantoprazole sodium sesquihydrate in the form of enteric-coated granules in unit dose packets.
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Pantoprazole and the added internal standard, omeprazole, were extracted from sodium heparinized human plasma using liquid-liquid extraction.
Los datos se obtuvieron mediante informes de los mismos participantes, lo que conduce a una sobreestimacin notable.
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Pantoprazole sodium USP is a white to off-white powder and is racemic.
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For information on systemic interactions resulting from concomitant use, see Interactions.
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Dexrabeprazole is an R-isomer of rabeprazole and its efficacy has been confirmed in animal studies at half the dose of the racemate (rabeprazole) with the R-isomer being more effective than S-isomer in aspirin-induced ulcers.
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The critical role of CYP2C19 in the in vivo clearance of the drugs is further demonstrated by the fact that healthy volunteers that are PMs of this enzyme achieve approximately 6-fold higher pantoprazole exposure than those who are extensive metabolizers of CYP2C19(20).
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