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What is methotrexate used to treat? Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites.
How much methotrexate should I take for cancer? For cancer : Adults—Dose is based on type of cancer and body size and must be determined by your doctor. A dose of 10 to 30 milligrams (mg) once per day may be given for several days and then repeated after a rest period. For some conditions, 5 to 50 mg once per week may be used.