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How dangerous is methotrexate? Other severe (but rare) side effects include lung and liver damage with long-term usage. People prescribed methotrexate will be closely monitored by their doctor for these effects. In addition to being an effective treatment for rheumatoid arthritis, methotrexate reduces the risk of death from heart disease.
Do you have to take methotrexate at the same time? Your doctor will tell you when to take folic acid. Generally, you should avoid taking it on the same day as methotrexate, because it can affect how well it works.